Tag: male infertility

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After Cancer, Stem Cells Restore Male Fertility

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U. PITTSBURGH (US) — After an injection of banked sperm-producing stem cells, male primates who become sterile due to cancer drug side effects were once again fertile.

A study published in Cell Stem Cell, describes how previously frozen stem cells restored production of sperm that was able to successfully fertilize eggs to produce early embryos.

Some cancer drugs work by destroying rapidly dividing cells. Since it isn’t possible to discriminate between cancer cells and other rapidly dividing cells in the body, the precursor cells involved in making sperm can be inadvertently wiped out leaving the patient infertile, explains senior investigator Kyle Orwig, associate professor in the department of obstetrics, gynecology and reproductive medicine at the University of Pittsburgh School of Medicine, and an investigator at Magee-Womens Research Institute. Read full article.

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ASRM: Dietary Glycemic Load Linked to Sperm Concentration

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(HealthDay News) Increased carbohydrate intake and dietary glycemic load and increased intake of full-fat dairy products are associated with worse semen quality, according to two studies presented at the annual meeting of the American Society for Reproductive Medicine, held from Oct. 20 to 24 in San Diego.

Jorge E. Chavarro, M.D., Sc.D., from the Harvard School of Public Health in Boston, and colleagues examined the association between carbohydrate intake and semen quality using data from 189 men, aged 18 to 22 years, recruited for the Rochester Young Men’s Study in 2009 to 2010. The researchers found that there was a suggestion of an inverse association for total carbohydrate intake with sperm concentration (P = 0.08 for trend). Dietary glycemic load correlated with lower sperm concentration (P for trend = 0.04). Sperm motility and morphology were unrelated to carbohydrate intake or glycemic load. Read full article.

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Can Cheese Harm a Man’s Fertility?

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Young men who eat more than three slices of cheese a day may be risking their chances of becoming fathers, according to research. Even small amounts of full-fat dairy food have been shown to dramatically impair their fertility.

Harvard academics have discovered that men who eat just three portions a day had poorer quality sperm compared to others. A portion included an ounce of cheese (28g), a teaspoon of cream, a scoop of ice cream or glass of full-fat milk.

The researchers believe that female hormones that occur naturally in milk may be interfering with men’s ability to reproduce. Read full article.

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Protein Mutation Linked to Male Infertility

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Sydney: Mutations in a protein called RABL2 shortens sperm tails, crippling their swimming ability (motility) and lowering sperm production – all contributing to male infertility, says a study.

The team led by Moira O`Bryan, professor from Monash University`s School of Biomedical Sciences in Austraia, found that mutated RABL2 resulted in sperm tails 17 percent shorter than normal, lowering sperm production by 50 percent.

O`Bryan said the research fitted another piece in the jigsaw puzzle of sperm development. “The mutations in the RABL2 gene are very likely to cause infertility,” said O`Bryan, the journal Public Library of Science Genetics reports. Read full article.

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Spur On Your Sperm

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Want your “guys” to swim like Ryan Lochte and Michael Phelps — good kick, perfect physique and great speed? Well, you can spur on your sperm by adding walnuts to your daily menu. (Mike likes ’em roasted; Mehmet? Soaked in water.) Turns out this nut is packed with alpha linoleic acid, one of the omega-3s that help protect you from inflammation and associated diseases, such as diabetes, atherosclerosis and osteoporosis. Read full article.

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Chinese Hospital Introduces Sperm Extractor

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A hospital in China is introducing a sperm extractor to help men who have infertility problems.

The hands-free device has an adaptable massager that can be adjusted according to the person’s height. A website that’s selling the machine for $2,800 says “it can give patients very comfortable feeling.” Read full article.

 

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Male Fertility Restored with Missing Sperm Protein

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Male infertility can be the result of sperm missing just one vital protein, which is necessary to activate the egg when the sperm fuses with it. But injecting that egg with the missing protein can “kick-start” the vital processes of embryo development, and dramatically increase the chances of a successful pregnancy.

These are the findings of a new study by a team at Cardiff University in the UK who write about their work in a paper being published in the journal Fertility and Sterility. They suggest the findings strengthen the case for the potential use of the protein in treating male infertility. Read full article.

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‘Missing’ protein can kick-start male fertility

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Adding a missing protein to in fertile human sperm can ‘kick-start’ its ability to fertilise an egg and dramatically increase the chances of a successful pregnancy, a new study has claimed.

Researchers from Cardiff University have found that sperm transfers a vital protein, known as PLC-zeta (PLCz), to the egg upon fertilisation.

This sperm protein initiates a process called ‘egg activation’ which sets off all the biological processes necessary for development of an embryo. Read full article.

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Sperm Precursor Cells Made in Lab Could One Day Restore Male Fertility

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(Medical Xpress)—Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can be coaxed into becoming precursor sperm cells, suggesting that it might be possible one day to restore fertility for sterile males with an easily obtained skin sample, according to researchers at the University of Pittsburgh School of Medicine. Their findings are available today in the online version of Cell Reports. Read full article.
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Sperm ‘Grown’ From Skin Cells Could Help Male Fertility

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A breakthough in aiding male infertility may have been made as researchers ‘grow’ early stage sperm from human skin cells.

Scientists at University of Pittsburgh School of Medicine carried out research to see whether they could induce adult cells and make them develop as a different type of cell.

The findings could greatly help male infertility and the increase the chance of childhood cancer sufferers being able to father children. Read full article.