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New Drug Compounds Show Promise Against Endometriosis

Two new drug compounds – one of which has already proven useful in a mouse model of multiple sclerosis – appear to be effective in treating endometriosis, a disorder that, like MS, is driven by estrogen and inflammation, scientists report in Science Translational Medicine.

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Conceiving The Possibilities: The Management of Infertility in Women with Endometriosis

Endometriosis is a poorly understood, progressive disease affecting women in their reproductive years. It creates an inflammatory environment in the pelvis and reproductive system, leading to the development of adhesions (scar tissues) and endometriomas (cysts known as chocolate cysts), which cause chronic pelvic pain symptoms and can compromise fertility.  

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Just How Terrible Is Endometriosis?

Few diagnoses are more upsetting for women than endometriosis. Of course, the various female cancers, heart disease, and other life-threatening diseases and disorders are devastating, but endometriosis is a diagnosis that may well mean lifelong troubles ranging from menstrual pain to bowel or bladder dysfunction to infertility, while also possibly making a woman more prone to some of the other devastating health issues. A new study by Monash University researchers confirms just how burdensome a diagnosis of endometriosis can be.

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New Mouse Model ‘Opens Doors to Better Understanding of Endometriosis’

Approximately 176 million women and girls worldwide have endometriosis. But regardless of its widespread occurrence, there is still little known about what causes the condition. Now, researchers have created a mouse model of endometriosis that they say will provide a better understanding of its development and may lead to improved treatment.

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New Research Provides Better Understanding of Endometriosis

A mouse model of endometriosis has been developed that produces endometriosis lesions similar to those found in humans, according to a report published in The American Journal of Pathology. This model closely mirrors the human condition as an estrogen-dependent inflammatory disorder, and findings from the study suggest that macrophages present in shed endometrium contribute to the development of the lesions.

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Endometriosis, Fibroids, and Diet

Endometriosis is a condition where tissues similar to those lining the cavity of the uterus are present outside the actual lining of the uterus. It may be found in the muscles of the uterus (Adenomyosis) around the Fallopian tubes, on the surface of the bowel, bladder, peritoneal surfaces in the abdomen and pelvis and sometimes rarely in the vagina and lungs. These deposits shed under the influence of the hormones produced by the ovaries (oestrogen and progesterone) in a similar fashion to the shedding of the lining of the uterus during the menstrual period. This results in bleeding at the various sites, causing scarring or adhesions to form.