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New breast cancer clues found in gene analysis

Scientists reported Sunday that they have completed a major analysis of the genetics of breast cancer, finding four major classes of the disease. They hope their work will lead to more effective treatments, perhaps with some drugs already in use.

The new finding offers hints that one type of breast cancer might be vulnerable to drugs that already work against ovarian cancer.

The study, published online Sunday by the journal Nature, is the latest example of research into the biological details of tumors, rather than focusing primarily on where cancer arises in the body. Read full article.

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Breast Cancer at 23

Six months ago, Slayton Haney was like so many other twenty-somethings fresh out of college: newly on her own and just settling into her life and career as an adult. After graduating from Florida State University in 2011 with a degree in finance, she got a job as an accountant at the Ritz-Carlton in Orlando, where she moved in with a friend from school. Life was good.

Then, in May, Haney felt something in her breast. A lump. Read full article.

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Jury to Decide if Hormone Therapy Caused Utah Woman’s Breast Cancer

More than eight years after alleging hormone therapy drugs caused and promoted her breast cancer, Toshiko Okuda is finally getting her day in court.

Okuda was among dozens of Utah women — and thousands nationwide — who filed federal civil lawsuits against Wyeth and other drug manufacturers after researchers halted a National Institutes of Health sponsored study in 2002 upon finding an increased risk of invasive breast cancer among those using hormone replacement drugs. Her lawsuit, along with 68 others filed in Utah, was initially transferred to the Eastern District of Arkansas; three were remanded back to Utah’s district court in April 2010. Read full article.

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Fertility Drugs’ Link to Breast Cancer Hinges on Pregnancy, Study Says

Do fertility drugs affect a woman’s risk of developing breast cancer? A new study suggests that the risk hinges on whether they actually help a woman get pregnant.

Scientists have been concerned about the effects of fertility drugs in recent years, citing a possible relationship between the hormones altered by the drugs and those implicated in breast cancer. Studies attempting to pinpoint the link between fertility drugs and cancer risk have varied widely in their conclusions. Some have found a reduction in cancer risk, some an increased risk. Others found no connection at all.

But researchers at the National Institutes of Health found that although the drugs seem to reduce breast cancer risk in young women, the risk goes up when they get pregnant.

Researchers studied pairs of sisters, in total following more than 1,400 women who had been diagnosed with breast cancer before age 50 and more than 1,600 of their sisters who had never had breast cancer. Of these women, 288 reported using ovulation-stimulating fertility drugs, clomiphene citrate and follicle-stimulating hormone, at some point; 141 women reported a pregnancy lasting 10 weeks or more after taking the drugs.

Read full article.

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IVF Treatment and Overall Rate of Breast Cancer…

In a large population-based study out of Western Australia, researchers have found that IVF is not associated with an overall increased risk of breast cancer. However, the analysis of 20 years’ worth of linked hospital and registry records demonstrates an underlying, age-related connection between IVF treatment and breast cancer.  The effect of IVF on breast cancer rates differed depending on the age of the women at the time treatment was commenced.  In younger, but not older, patients there was an association between having IVF and an increased risk of breast cancer.