When you think about the subject of infertility, it is customary to focus on the challenges faced by women who may have to suffer though an expensive and physically demanding process known as In-Vitro Fertilization. This long road entails procedures to harvest the eggs from the ovaries, implant the embryos in the uterus and then carry a stressful pregnancy, frequently complicated by multiple gestations and the risk of miscarriage to term. However, as we all know, it ‘takes two to tango’ and often there is less discussion and awareness of the male side of the equation. Indeed, it is estimated that 40-50% of human infertility can be explained by ‘male factors’, and science is increasingly gaining insight into the requirements necessary for healthy male fertility.