In the WHI study, women were in their 60´s when they began taking hormones, in this study, the average age of the women was only 50 when they first began using HT. This study much more closely resembles the use of HT in clinical practice. Data from WHI in women aged 50-59 also showed that women receiving estrogen alone had a significantly reduced rate of CVD and a reduced mortality in the 11 year follow-up.