SANTA BARBARA, CALIF. – Although there are hints, researchers remain largely baffled about why ethnic minority patients have lower pregnancy and live birth rates than do whites when they undergo in vitro fertilization, especially as natural conception rates do not appear to be disparate.
Many potential explanations have been hypothesized, including differences in obesity rates, leiomyomata prevalence, inflammatory processes, and estrogen metabolism, Dr. Marcelle I. Cedars said at a meeting on in vitro fertilization and embryo transfer, which was sponsored by the University of California, Los Angeles.
None seem to fully account for diminished IVF outcomes in Asian Americans, blacks, and Hispanics. Pregnancy loss rates associated with assisted reproductive techniques also are higher for blacks and Hispanics, she noted.
Economic disparities and unequal access to IVF have been suggested as playing a role, but military studies, in which all patients have equal access to care, confirm reduced outcomes numerically – although the numbers did not quite reach statistical significance.
Dr. Cedars’ group at the University of California, San Francisco (UCSF), has focused on IVF outcomes in Asian Americans, who represent approximately a third of their patient population. Differences came under scrutiny beginning about 6 years ago. Read full article.
